Noltrexate 10mg Tablet
Manufacturer
Knoll Pharmaceuticals Ltd
Salt Composition
Methotrexate (10mg)
Key Information
Short Description
Noltrexate 10mg Tablet is a medicine used for treatment of cancer in various parts of the body, rheumatoid arthritis, severe and uncontrolled psoriasis, and Crohn's disease.
Dosage Form
Tablet
Introduction
Noltrexate 10mg Tablet may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised. Taking too much of it can cause serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid consumption of alcohol while taking this medicine as it may increase your risk of liver damage. The most common side effects of this medicine are ulcerative stomatitis, hair loss, low blood cell count, increased liver enzymes, nausea, and abdominal distress. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine to check for these.
Directions for Use
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush, or break it. Noltrexate 10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Safety Information
Side Effects
ulcerative stomatitis hair loss low blood cell count increased liver enzymes nausea abdominal distress
Alcohol Warning
It is unsafe to consume alcohol with Noltrexate 10mg Tablet.
Breastfeeding Warning
Noltrexate 10mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Pregnancy Warning
Noltrexate 10mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Interacting Medicines
Rotavirus vaccine (live attenuated, oral) Live Attenuated Varicella-Zoster Virus Measles Vaccine (Live) Rubella vaccine (Live)
How it works
Noltrexate 10mg Tablet inhibits enzymes (dihydrofolate reductase), prevents cell division and leads to anti-inflammatory actions. Noltrexate 10mg Tablet kills cancer cells by preventing them from making DNA. Noltrexate 10mg Tablet can help control psoriasis by retarding the production of skin cells and suppressing inflammation. Noltrexate 10mg Tablet may treat rheumatoid arthritis by suppressing the immune system, preventing it from attacking the body's cells. This helps reduce the inflammation that causes swollen and stiff joints in rheumatoid arthritis or damage to bowel in Crohn's disease.
Quick Tips
Drink plenty of liquids to stay hydrated while taking this medication. Take folic acid if advised by your doctor. This will help lessen the side effects of this medicine. It may take from weeks to months for Noltrexate 10mg Tablet to work. Keep taking the medication as prescribed. Your doctor may get regular blood test done to monitor your kidney function, liver function, and level of blood cells in your blood. Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects. It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
Related Medicines
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Methate 10mg Tablet
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Frequently asked questions
Can Noltrexate 10mg Tablet cause mouth ulcers?
Yes, Noltrexate 10mg Tablet may cause a sore mouth and mouth ulcers in some individuals as a side effect. Taking folic acid along with this medicine may help reduce the likelihood of these side effects. It is recommended to discuss dose reduction with your doctor to see if it could further help.
Why am I required to take folic acid while taking Noltrexate 10mg Tablet?
Folic acid plays a vital role in the production of new cells. Noltrexate 10mg Tablet may decrease folic acid levels in the body, which is why it's important to use folic acid along with this medication. Folic acid can help minimize common side effects like mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia, and liver problems.
Why do I need regular blood tests while taking Noltrexate 10mg Tablet?
Regular blood tests help your doctor assess your response to Noltrexate 10mg Tablet and monitor for potential side effects. This allows them to check your liver function and blood cell counts (white blood cells, red blood cells, and platelets). The results will guide further treatment adjustments.
Can Noltrexate 10mg Tablet make me more prone to infections?
Noltrexate 10mg Tablet may suppress the activity of your immune system. This could increase the risk of developing serious infections. There have been rare reports indicating a potential for lung infections following Noltrexate 10mg Tablet use. For those with active infections, using Noltrexate 10mg Tablet needs to be done with extreme caution.
Can Noltrexate 10mg Tablet affect fertility?
Yes, Noltrexate 10mg Tablet can potentially impact fertility in both men and women. It may reduce sperm count in men and cause menstrual irregularities in women. These effects are temporary and reversible once treatment is discontinued.
What should I do if I am planning to become pregnant while my husband is taking Noltrexate 10mg Tablet?
It is recommended to avoid pregnancy if your husband is currently taking Noltrexate 10mg Tablet. Additionally, it is advisable to delay conception for at least three months after the therapy ends as this could lead to significant fetal abnormalities.
