Torrent Pharmaceuticals Ltd
Propranolol (40mg) + Flunarizine (10mg)
Nigrain Plus 40mg/10mg Tablet is a combination of two medicines that helps in preventing migraine.
Tablet
Nigrain Plus 40mg/10mg Tablet should be taken on empty stomach but try to have it same time regularly at a fixed time preferably at night. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Lifestyle modifications like avoiding stress, smoking, and processed food items may help this medicine work better.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nigrain Plus 40mg/10mg Tablet is to be taken empty stomach.
Nigrain Plus 40mg/10mg Tablet is a combination of two medicines: Propranolol and Flunarizine which prevents migraine. Propranolol is a beta blocker and Flunarizine is a calcium channel blocker. They work by stabilizing the reactive nerve cells and increasing the threshold to migraine activation. They also inhibit cortical spreading depression (CSD- electric waves that move across the brain and cause pain and inflammation.)
Have your meals at the same time everyday Avoid bright lights and extreme temperatures Avoid loud music and noisy places Avoid chocolates Avoid cheese Avoid processed food Avoid alcohol and smoking Get sufficient sleep and avoid stress It should be taken at night-time before going to bed. It may cause sleepiness. Don't drive or do anything that requires mental focus until you know how Nigrain Plus 40mg/10mg Tablet affects you. Keep taking it regularly every day, even if you don't have any symptoms.
The use of Nigrain Plus 40mg/10mg Tablet is contraindicated in patients with an allergy to any of its ingredients or excipients. Additionally, it is not recommended for patients with asthma, slow heart rate, abnormal heart rhythms, or heart conditions such as AV block or sick sinus syndrome, due to the presence of propranolol. Furthermore, patients with a history of depression or Parkinson's disease should avoid using this medicine, given the presence of flunarizine.
Store Nigrain Plus 40mg/10mg Tablet in its original container, tightly closed, according to the instructions on the pack or label. Dispose of any unused medication, ensuring it is not accessible to pets, children, or other individuals.
Nigrain Plus 40mg/10mg Tablet is a prophylactic treatment for preventing migraine headaches. It is essential to continue taking this medication as directed by your doctor, as stopping it abruptly may lead to a recurrence of migraine episodes. The medicine contains propranolol, and sudden withdrawal may cause symptoms such as sweating, shaking, irregular or fast heartbeat, or worsening of underlying angina or heart attack. Always follow your doctor's advice regarding the use of Nigrain Plus 40mg/10mg Tablet.
Nigrain Plus 40mg/10mg Tablet is not intended to relieve a migraine headache that has already started. It is only effective in preventing new episodes of migraine headaches.