Neovorin Injection
Manufacturer
Neon Laboratories Ltd
Salt Composition
Calcium Leucovorin (50mg)
Key Information
Short Description
Neovorin Injection is used to prevent the harmful effects of methotrexate (anticancer medicine) and treat overdose of methotrexate.
Dosage Form
Injection
Introduction
Neovorin Injection is given as a slow injection into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects.
Directions for Use
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
How it works
Neovorin Injection is a form of vitamin B. It works by protecting healthy cells from the toxic effects of methotrexate (anticancer medicine) while allowing it to enter and kill the cancer cells.
Quick Tips
You have been prescribed Neovorin Injection to reduce the side effects of the medicine methotrexate. Take it 24 hours after taking methotrexate. If taken at the same time it may counteract the effect of methotrexate. Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Neovorin Injection may counteract the antiepileptic effects.
Frequently asked questions
What is Neovorin Injection used for?
Neovorin Injection is a medication used to prevent the harmful effects of methotrexate, a chemotherapy medication used to treat certain types of cancer. It is also used to treat accidental overdoses of methotrexate or similar medications. Additionally, Neovorin Injection is used to treat megaloblastic anemia caused by folic acid deficiency when oral therapy is not feasible.
What is megaloblastic anemia?
Megaloblastic anemia is a type of anemia characterized by large red blood cells and a decrease in their number. It is usually caused by vitamin B12 or folic acid deficiency, leading to insufficient oxygen delivery to tissues and organs.
How long does it take for Neovorin Injection to work?
Neovorin Injection starts working within 5 minutes of administration, but the exact duration and effectiveness may vary depending on factors such as dosage, patient response, and treatment requirements.
What laboratory tests are conducted before or during treatment with Neovorin Injection?
Before or during treatment, your doctor will perform blood tests to monitor serum methotrexate concentration, complete blood count (to check red blood cell levels), and calcium levels to prevent hypercalcemia associated with Neovorin Injection.
What measures should be taken to ensure prompt excretion of methotrexate during treatment with Neovorin Injection?
To facilitate methotrexate excretion, it is essential to maintain urine output above 2,500 mL/24hr, alkalinize the urine (with a pH greater than 7.0), and avoid foods, drinks, or medications that may increase urinary acidity. Blood methotrexate concentration should be measured at least once every 24 hours for the first 72 hours after initiating the methotrexate infusion.
