Neovorin 15mg Injection
Manufacturer
Neon Laboratories Ltd
Salt Composition
Calcium Leucovorin (15mg)
Key Information
Short Description
Neovorin 15mg Injection is used to prevent the harmful effects of methotrexate (anticancer medicine) and to treat overdose of methotrexate.
Dosage Form
Injection
Introduction
Neovorin 15mg Injection is given as a slow injection into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects.
Directions for Use
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
How it works
Neovorin 15mg Injection is a form of vitamin B. It works by protecting healthy cells from the toxic effects of methotrexate (anticancer medicine) while allowing it to enter and kill the cancer cells.
Quick Tips
You have been prescribed Neovorin 15mg Injection to reduce the side effects of the medicine methotrexate. Take it 24 hours after taking methotrexate. If taken at the same time it may counteract the effect of methotrexate. Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Neovorin 15mg Injection may counteract the antiepileptic effects.
Frequently asked questions
What is Neovorin 15mg Injection used for?
Neovorin 15mg Injection is used to prevent the harmful effects of methotrexate (a cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. It is also used to treat individuals who have accidentally received an overdose of methotrexate or similar medications. Additionally, Neovorin 15mg Injection is used to treat megaloblastic anemia caused by folic acid deficiency, particularly in cases where oral therapy is not feasible.
What is megaloblastic anemia?
Megaloblastic anemia is a type of anemia characterized by the production of abnormally large red blood cells and a decrease in the number of those cells. This condition is often caused by a deficiency of vitamin B12 or folic acid. Anemia is a blood disorder in which the number of red blood cells that carry oxygen is lower than usual, resulting in inadequate oxygen supply to tissues and organs.
How long does it take for Neovorin 15mg Injection to work?
Neovorin 15mg Injection starts acting on the body within 5 minutes of administration. However, the exact timing of its effects may vary depending on the dosage, the patient receiving the drug, and their individual response to treatment.
What are some of the laboratory tests conducted before or during the treatment with Neovorin 15mg Injection?
Your doctor may order blood tests to monitor your serum methotrexate concentration (in cases of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Neovorin 15mg Injection. Additionally, complete blood counts will be performed to monitor the number of red blood cells (in cases of megaloblastic anemia). Calcium levels will also be monitored to prevent hypercalcemia, as Neovorin 15mg Injection contains calcium.
What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Neovorin 15mg Injection?
To ensure prompt excretion of methotrexate, it is essential to maintain urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. Monitoring alkalinization of urine (which enhances drug excretion) to ensure a urinary pH greater than 7.0 before methotrexate infusion is also crucial. Avoiding foods, drinks, and drugs that may increase urinary acidity during therapy is also important. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.
