Kerendia 20mg Tablet
Manufacturer
Bayer Zydus Pharma Pvt Ltd
Salt Composition
Finerenone (20mg)
Key Information
Short Description
Kerendia 20mg Tablet is a medicine used to treat chronic kidney disease (CKD) caused by type 2 diabetes (T2D). It works by blocking a certain hormone in the body, which can help prevent the kidneys from getting worse and reduce the risk of heart-related issues.
Dosage Form
Tablet
Introduction
Kerendia 20mg Tablet is a nonsteroidal selective antagonist of the mineralocorticoid receptor (MR). It is used to treat chronic kidney disease (CKD) caused by type 2 diabetes (T2D). It works by blocking a certain hormone in the body, which can help prevent the kidneys from getting worse and reduce the risk of heart-related issues like heart attacks and heart failure.
Directions for Use
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Kerendia 20mg Tablet may be taken with or without food but it is better to take it at a fixed time.
How it works
Kerendia 20mg Tablet is a nonsteroidal selective antagonist of the mineralocorticoid receptor (MR). This receptor usually activated by hormones like aldosterone and cortisol helps in controlling sodium levels in the body. Kerendia 20mg Tablet blocks and prevents this receptor from overactivation which can damage different parts of the body such as the kidneys, heart and blood vessels.
Quick Tips
For patients who are unable to swallow whole tablets, Kerendia 20mg Tablet may be crushed and mixed with water or soft foods before taking it. Inform your doctor if you are taking potassium supplements or any other medications for high blood pressure or heart disease. Women of childbearing potential should use effective contraception during the treatment to avoid getting pregnant. Kerendia 20mg Tablet contains lactose; inform your doctor if you have lactose intolerance. Lactating women should exercise cautions while on treatment with this medicine.
Frequently asked questions
What precautions should breastfeeding women take when considering treatment with Kerendia 20mg Tablet?
Breastfeeding women should exercise caution while on treatment with this medicine. They should consult their doctor for guidance.
Does Kerendia 20mg Tablet reduce the risk of heart failure events in high-risk patients?
Yes, a study reported that Kerendia 20mg Tablet reduces new-onset of heart failure and improves other heart failure outcomes in patients with chronic kidney disease and type 2 diabetes, irrespective of a history of heart failure or heart disease.
What is the risk of potassium level increase with Kerendia 20mg Tablet?
Yes, Kerendia 20mg Tablet may result in hyperkalemia (increased potassium level), especially in patients with reduced kidney function and with already high potassium levels. The doctor may monitor the patient's potassium level before and during treatment, and adjust the dose accordingly.
What is the dosing frequency of Kerendia 20mg Tablet based on eGFR?
The initial dose of Kerendia 20mg Tablet is 20 mg daily for an estimated glomerular filtration rate (eGFR) of ≥ 60 mL/min and 10 mg daily for an eGFR of ≥ 25 to < 60 mL/minute. This medicine is not recommended for patients with an eGFR < 25 mL/min. The doctor may also adjust the dose if the patient has a high potassium level.
What are the breastfeeding guidelines for Kerendia 20mg Tablet?
Breastfeeding is not recommended during treatment with this medicine and for 1 day after the treatment.
Is low blood pressure a potential side effect of Kerendia 20mg Tablet?
Yes, Kerendia 20mg Tablet may cause a decrease in blood pressure that can lead to hypotension.
