Comezole 20 Capsule
Manufacturer
Candela Healthcare
Salt Composition
Omeprazole (20mg)
Key Information
Short Description
Comezole 20 Capsule is a medicine that reduces the amount of acid produced in your stomach, used in the treatment of acid-related diseases of the stomach and intestine such as heartburn, acid reflux, peptic ulcer disease, and Zollinger-Ellison syndrome.
Dosage Form
Capsule
Introduction
Comezole 20 Capsule is best taken one hour before a meal, preferably in the morning. The dose will depend on your underlying condition and how you respond to the medicine. You should keep on taking it as prescribed even if your symptoms disappear quickly. You can increase the efficiency of the treatment by eating smaller meals more often and avoiding caffeinated drinks (like tea and coffee) and spicy or fatty foods.
Directions for Use
Take this medicine in the dose and duration as advised by your doctor. Comezole 20 Capsule is to be taken empty stomach.
How it works
Comezole 20 Capsule is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which provide relief from symptoms of heartburn, acid reflux, peptic ulcer disease, and Zollinger-Ellison syndrome.
Quick Tips
Avoid excessive intake of carbonated beverages/soft drinks citrus juices fried food caffeinated beverages like tea and coffee. Avoid alcohol and smoking. Avoid eating late at night or before bedtime. Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away. Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention. Long-term use of Comezole 20 Capsule can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor. Do not stop taking medication without talking to your doctor. Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.
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Frequently asked questions
Can I take Comezole 20 Capsule with domperidone?
This medicine can be safely taken with domperidone, as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone works by increasing gut motility and Comezole 20 Capsule decreases the acid production in the stomach. This combination is very effective in treating reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.
What should I know before taking Comezole 20 Capsule?
You should not take it if you are taking a medicine containing atazanavir and nelfinavir (used for HIV infection). If you are experiencing liver problems, persistent diarrhea, or vomiting, black stools (blood-stained stools), unusual weight loss, trouble swallowing, stomach pain or indigestion, let your doctor know. Tell your doctor about all the other medicines you are taking because they may affect, or be affected by, this medicine. Inform your doctor if you have or ever had an allergic skin reaction with this medicine. It should not be given to children under 1 year of age or whose body weight is less than 10 kgs. Pregnant and breastfeeding mothers should consult their doctor before taking this medicine to avoid potential harm to the baby.
Can Comezole 20 Capsule cause diarrhea?
Yes, it may cause diarrhea as a side effect in some people. This is usually not bothersome, but if you experience persistent watery stools that do not go away, along with stomach cramps and fever, get medical help immediately.
For how long can Comezole 20 Capsule be taken?
Take it for as long as advised by your doctor. The duration may vary depending on your condition. Do not stop taking this medicine without talking to your doctor.
Can Comezole 20 Capsule cause calcium deficiency and osteoporosis?
It can increase the risk of calcium deficiency and osteoporosis (thinning of bones) because it decreases calcium absorption. This is a concern for long-term use. Inform your doctor if you have osteoporosis or are taking corticosteroids (which can increase the risk of osteoporosis), before starting therapy. Consult your doctor on ways to prevent this. Your doctor may advise calcium or vitamin D supplements to reduce the risk.
What are the long term side effects of Comezole 20 Capsule?
Using Comezole 20 for more than 3 months can lead to certain long-term side effects. These include low magnesium levels in the blood, which may cause fatigue, confusion, dizziness, shakiness, or lightheadedness. You may also experience muscle twitches or irregular heartbeat. Prolonged use (over a year) increases risk of bone fractures due to decreased calcium levels in the blood, especially at hip, wrist, or spine fracture sites. Vitamin B12 deficiency can lead to anemia and tiredness, making you pale, weak, and feeling less energetic. Additionally, you may experience palpitations, shortness of breath, lightheadedness, indigestion, loss of appetite, flatulence (gas), or nerve problems such as numbness, tingling, and difficulty walking.
Does Comezole 20 Capsule cause vitamin deficiencies?
It may cause vitamin B12 and vitamin C deficiency. When taken orally, vitamin B12 requires an acidic environment for its absorption from the stomach while this medicine causes a decrease in gastric acid secretion. You may need to take vitamin B12 supplements along with it. The clinical significance of the decrease in vitamin C levels is not known, so vitamin C supplementation is not recommended.
Can Comezole 20 Capsule be used in cardiac patients?
Cardiac patients can take this medicine as prescribed by their doctor. However, some drugs they are taking might interact with Comezole 20 (such as clopidogrel or digoxin) which should be monitored closely by a doctor.
