Combinib 250mg Tablet
Manufacturer
Cipla Ltd
Salt Composition
Lapatinib (250mg)
Key Information
Short Description
Combinib 250mg Tablet is used in the treatment of breast cancer. It works by stopping or slowing down the growth of cancer cells.
Dosage Form
Tablet
Introduction
Combinib 250mg Tablet should be taken on an empty stomach or an hour before or 2 hours after a meal. The dose and duration vary according to the severity of your condition and your response to treatment. Take it exactly as prescribed to avoid serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Directions for Use
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combinib 250mg Tablet is to be taken empty stomach.
How it works
Combinib 250mg Tablet is an anti-cancer medication. It works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which are responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways.
Quick Tips
It should be taken 1 hour before or 2 hours after the meal preferably at the same time every day Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools. Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it. Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting. It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools. Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
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Frequently asked questions
Is Combinib 250mg Tablet a chemotherapy medicine?
No, this is a targeted drug that belongs to a class of anti-cancer medicines. They are more specific than chemotherapy in their mechanisms of action. Combinib 250mg Tablet belongs to the tyrosine kinase inhibitors group of medicines. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.
Can Combinib 250mg Tablet be given in combination with other anti-cancer drug?
Yes, Combinib 250mg Tablet can be used with other anti-cancer drugs. It is often used in combination with capecitabine to treat advanced breast cancer in patients who have already been treated with chemotherapy. Combinib 250mg Tablet is also used with letrozole to treat breast cancer in post-menopausal women.
How should I take Combinib 250mg Tablet?
Take Combinib 250mg Tablet exactly as advised by your doctor. Swallow the tablet whole with a glass of water at the same time each day. You must take Combinib 250mg Tablet 1 hour before or 1 hour after meals and at the same time concerning food each day (e.g., you could always take your tablet one hour before breakfast).
Does Combinib 250mg Tablet have any effect on the liver?
Combinib 250mg Tablet may cause liver damage which can be severe or life-threatening. Liver damage can occur as soon as several days or as late as several months after the start of treatment with Combinib 250mg Tablet. Inform your doctor if you have or had liver disease. If you experience any symptoms such as itching, change in color of the skin or eyes (yellowing), discoloration of urine, pain in the upper right part of the stomach, unusual bleeding or bruising, or pale or dark stools, call your doctor immediately.
How should I manage diarrhea while taking Combinib 250mg Tablet?
If you suffer from diarrhea while taking Combinib 250mg Tablet, you should drink plenty of fluids (8 to 10 glasses a day) such as water, sports drinks, or other clear liquids. You should eat low-fat, high protein foods instead of fatty or spicy foods. Eating cooked vegetables instead of raw vegetables and removing the skin from fruits before eating can also be helpful. Try to avoid milk and milk products (including ice cream) and herbal supplements (some may cause diarrhoea). Inform the doctor, if the condition persists, who may interrupt the treatment depending on the severity of diarrhea.
How can I take care of my skin while on Combinib 250mg Tablet?
Your doctor will check your skin before and during the treatment. If you have sensitive skin, use a soap-free cleanser and beauty products that are fragrance-free and hypoallergenic. It is also advised that you use sunscreen with an SPF (Sun Protection Factor) of 30 or higher. Inform your doctor immediately if you get a rash.
What tests will the doctor advise before starting Combinib 250mg Tablet?
You may need extra tests to check that your heart and liver are working properly. Combinib 250mg Tablet may change the way your heart beats and pumps blood through your body. Your doctor will monitor you carefully to see whether Combinib 250mg Tablet has affected your heart. Along with that, your doctor will get your liver function investigated. Based on the results of these tests, the doctor will decide whether dose adjustment or discontinuation of treatment is required.
How long after Combinib 250mg Tablet can I plan pregnancy?
Use an effective method of contraception to avoid pregnancy while you are taking Combinib 250mg Tablet and continue for at least 1 week after the last dose. Inform your doctor if you become pregnant, who will decide whether to stop or continue treatment.
