Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection
Manufacturer
Cipla Ltd
Salt Composition
Casirivimab (120mg) + Imdevimab (mg)
Key Information
Short Description
Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection is a combination of two monoclonal antibodies used together for the emergency treatment of mild to moderate COVID-19 in adults and children aged 12 years and above and over 40 kg in weight.
Dosage Form
Injection
Introduction
This monoclonal antibody cocktail received emergency use approval from the Central Drug Standard Control Organization (CDSCO) on May 3rd 2021. Apart from India, it has been approved for use in the United States, Switzerland, Germany, Italy, France, and several other countries. Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection should be given either into a vein (intravenously) or below the skin (subcutaneously) by a trained healthcare professional, preferably in a hospital setup. This is because the use of monoclonal antibodies may cause some side effects that may need immediate medical attention, such as severe allergic reactions (anaphylaxis). Patients should be monitored during and at least 1 hour after the injection.
Directions for Use
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
Safety Information
Side Effects
No common side effects listed.
Alcohol Warning
It is not known whether it is safe to consume alcohol with Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection. Please consult your doctor.
Breastfeeding Warning
Information regarding the use of Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection during breastfeeding is not available. Please consult your doctor.
Pregnancy Warning
Information regarding the use of Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection during pregnancy is not available. Please consult your doctor.
How it works
Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection is a combination of two human immunoglobulins G-1 (IgG1) neutralizing monoclonal antibodies that bind at different sites on the spike protein of SARS-CoV-2, the virus that causes COVID-19. This unique binding mechanism, developed using recombinant DNA technology, is equally effective against the existing as well as newer emerging variants and prevents the virus from attaching to the human cell receptors.
Quick Tips
Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection a monoclonal antibody cocktail therapy used to treat mild to moderate symptoms of COVID-19 in non-hospitalized adults and adolescents aged 12 years and older who weigh at least 40 kg The use of monoclonal antibodies is not indicated in severe hospitalized cases of COVID-19 or in those who require oxygen therapy. Even after the treatment, you should continue to practice (COVID)-appropriate behavior such as wearing a mask, social distancing, avoiding sharing personal items, and frequent handwashing. Before taking this antibody cocktail therapy, inform your doctor if you have any underlying medical conditions like diabetes, heart disease, high blood pressure, kidney disease, asthma, etc. Patients should be monitored during treatment and at least one hour after the completion of the infusion. Severe allergic reactions might happen during and after the use of monoclonal antibodies. Inform your doctor or nurse immediately if you experience shortness of breath, rapid or slow heart rate, chest pain, swelling of the face or lips, sweating.
Frequently asked questions
What are monoclonal antibodies? How are they relevant to Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection?
Monoclonal antibodies are specific proteins that mimic the immune system's ability to fight against harmful microorganisms, such as viruses. Casirivimab and Imdevimab, the monoclonal antibodies present in Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection, help protect against SARS-CoV-2, the virus that causes COVID-19.
What is a monoclonal antibody cocktail?
A monoclonal antibody cocktail is a combination of monoclonal antibodies that are available separately, but are mixed together for use as a cocktail, hence the name.
How are monoclonal antibodies helpful in treating COVID-19?
SARS-CoV-2, the virus that causes COVID-19, has a spike protein on its surface that helps the virus attach and enter the human body. Monoclonal antibodies are engineered to mimic this attachment with SARS-CoV-2, thereby preventing disease progression. Monoclonal antibody therapy may help in treating mild symptoms at the initial stages.
When should monoclonal antibody therapy for COVID-19 be taken?
Monoclonal antibody therapy for COVID-19 should be taken after early diagnosis of COVID-19 in patients aged 12 years or older with a bodyweight of at least 40 kg. It may also be taken by people who are at high risk of developing a severe infection, such as those aged 60 years or above, who have comorbidities like diabetes or hypertension, and those who are immunocompromised.
Who should not take monoclonal antibodies for COVID-19?
Monoclonal antibodies for COVID-19 should not be taken by individuals hospitalized or requiring oxygen therapy. Additionally, it should not be taken by those under oxygen treatment due to pre-existing comorbidities that may not be associated with COVID-19. Those who are allergic to any of the two medicines in Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection or any of the other ingredients of the kit should also avoid taking this combination of monoclonal antibodies.
Who is at high risk of developing severe COVID-19?
People aged above 60 years, who are obese, have comorbid conditions related to lungs, kidneys (like dialysis patients), liver, or those who have a weak immunity (like cancer patients) are at high risk of developing severe COVID-19.
How is Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection used?
Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection is given as an injection into a vein (intravenously) or below the skin (subcutaneously) by a healthcare professional in a hospital to treat mild to moderate symptoms of COVID-19. It should never be injected into a muscle (intramuscularly).
I have high blood pressure and diabetes. Can I take Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection?
Yes, Casirivimab & Imdevimab Combo Pack 120mg/120mg Injection can be taken by patients with high blood pressure or diabetes, if prescribed. As per the available data, the benefits of using monoclonal antibody therapy are more significant than the potential risks.
